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1961 |
Sidney Brenner, François Jacob, Matthew Meselson, identify messenger RNA |
|
1962 |
Pauling's
theory of molecular evolution |
|
1965 |
Margaret
Dayhoff's Atlas of Protein Sequences |
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1970 |
Needleman-Wunsch
algorithm |
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1977 |
DNA
sequencing and software to analyze it (Staden) |
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1981 |
Smith-Waterman
algorithm developed |
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1981 |
The
concept of a sequence motif (Doolittle) |
|
1982 |
GenBank
Release 3 made public |
|
1982 |
Phage
lambda genome sequenced |
|
1983 |
Sequence
database searching algorithm (Wilbur-Lipman) |
|
1985 |
FASTP/FASTN:
fast sequence similarity searching |
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1988 |
National
Center for Biotechnology Information (NCBI) created at NIH/NLM |
|
1988 |
EMBnet
network for database distribution |
|
1990 |
BLAST:
fast sequence similarity searching |
|
1991 |
EST:
expressed sequence tag sequencing |
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1993 |
Sanger
Centre, Hinxton, UK |
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1994 |
EMBL
European Bioinformatics Institute, Hinxton, UK |
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1995 |
First
bacterial genomes
completely sequenced |
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1996 |
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1997 |
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1998 |
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1999 |
Fly genome completely sequenced |
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1999 |
Fly
genome completely sequenced |
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2000 |
Jeong
H, Tombor B, Albert R, Oltvai ZN, Barabasi AL. The
large-scale organization of metabolic networks. Nature 2000
Oct 5;407(6804):651-4, PubMed
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2000 |
The
genome for Pseudomonas aeruginosa (6.3 Mbp) is published. |
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2000 |
The
A. thaliana genome (100 Mb) is secquenced. |
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2001 |
The
human genome (3 Giga base pairs) is published. |
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